A phospholipid / Tissue Factor preparation used for performing the Prothrombin Time. Source material for thromboplastin (Tissue Factor, factor III) is human brain or placenta (homologous sources), rabbit brain, lung or bovine brain (heterologous sources), or prepared by recombinant technology. Thromboplastins vary in their sensitivity to reductions in vitamin K-dependent proteins (FII, FVII, FIX, and FX).