Together with our colleagues from NOKLUS (Norway) we have performed a systematic review of published data on the biological variation for coagulation and fibrinolytic measurands.
The diagnosis and monitoring of bleeding and thrombotic disorders depend on correct haemostatic measurements. The availability of high-quality biological variation (BV) data is important in this context. Many studies have reported BV data for these measurands, but results are varied. The present study aims to deliver global within-subject (CVI) and between-subject (CVG) BV estimates for haemostasis measurands by meta-analyses of eligible studies, by assessment with the Biological Variation Data Critical Appraisal Checklist (BIVAC) (1).
This study provides updated BV estimates of CVI and CVG with 95% confidence intervals for a wide range of haemostasis measurands. These estimates can be used to form the basis for analytical performance specifications for haemostasis tests used in the diagnostic work-up required in bleeding- and thrombosis events and for risk assessment.
Clin Chem Lab Med 2023 Vol. 61 Issue 8 Pages 1470-1480
This publication can be downloaded via the following link: Systematic review and meta-analysis of within-subject and between-subject biological variation data of coagulation and fibrinolytic measurands (degruyter.com)
Reference:
1. Aarsand, A.K., T. Roraas, P. Fernandez-Calle, C. Ricos, J. Diaz-Garzon, N. Jonker, et al., The Biological Variation Data Critical Appraisal Checklist: A Standard for Evaluating Studies on Biological Variation. Clin Chem, 2018; 64: 501-514.