The International Council for Standardization in Haematology aims to publish guidance documents for a variety of topics relevant for the coagulation laboratory.
One of their guidance documents provide guidance and recommendations on the measurement of factor VIII (FVIII) and factor IX (FIX) inhibitors.
Abstract
This guidance document has been prepared on behalf of the International Council for Standardisation in Hematology. The aim of the document is to provide guidance and recommendations on the measurement of factor VIII (FVIII) and factor IX (FIX) inhibitors. After an introduction on the clinical background and relevance of factor VIII and factor IX inhibitor testing, the following aspects of laboratory testing are included: screening for inhibitors, assay principle, sample requirements, testing requirements and interpretation, quality assurance, interferences and recent developments. This guidance document focusses on recommendations for a standardised procedure for the laboratory measurement of FVIII and FIX type I inhibitors. The recommendations are based on published data in peer-reviewed literature and expert opinion.
Int J Lab Hematol, 2023; 45: 413-424.
This publication can be approached via the following link: International Council for Standardization in Haematology recommendations for laboratory measurement of factor VIII and FIX type I inhibitors – Meijer – 2023 – International Journal of Laboratory Hematology – Wiley Online Library