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Laboratory Tests

Analytical Information

Analytical performance specifications for hemostasis parameters
Assuring quality in the postanalytical phase
Comparison of two statistical software programs for determining reference intervals of screening coagulation assays
Critical pre-examination variables in hemostasis testing
Defining analytical performance specifications: Consensus Statement from the 1st Strategic Conference of the European Federation of Clinical Chemistry and Laboratory Medicine
Interference of rivaroxaban in one-stage and chromogenic factor VIII:C assays
Lupus anticoagulant testing: analyzing fresh samples after a single centrifugation and after a 6-8 hr delay
Pre-Analytical Issues in Platelet Function Testing – An Update
Results of a workshop on the inter-laboratory variability of analysis of type 1 factor VIII Inhibitors
Risk management for laboratory testing
The do’s and don’ts of laboratory detection of haemostasis-inhibitors: lessons from a workshop
The effect of Rivaroxaban on haemostasis assays; results from ECAT surveys
The responsiveness of different APTT reagents to mild factor VIII, IX and XI deficiencies
The use of quality indicators for the pre-analytical phase
Update on platelet aggregation testing

Assays

Clotting factor (II, V, VII and X)
Clotting factor (VIII, IX, XI and XII)
Factor VIII Inhibitor
- Factor VIII deficient plasma
- Normal pooled plasma
Factor XIII
- Factor XIII activity
- Factor XIII antigen
Fibrinolysis
Heparin Induced Thrombocytopenia
- Immunological test
Homocysteine
- Method
Screening
Thrombophilia
Von Willebrand Factor

Cases

A severe haemophilia A patient treated with emicizumab, case study
Acquired Glanzmann’s thrombasthenia
Acquired haemophilia A
Acquired Hemophilia A, case study
Dysfibrinogenemia, case study
Factor V Inhibitor
Haemophilia A and treatment, case study
Haemophilia B and treatment, case study
Hermansky Pudlak syndrome
Trauma-Induced Coagulopathy, case study
Von Willebrand Disease type 1, case study
Von Willebrand Disease type 2B, case study
Von Willebrand Jürgens syndrome type I, case study 2016
Von Willebrand Jürgens syndrome type I, case study 2019

ECAT Documentation

Meetings
- Meeting
- Webinars
Publications
- 1. Publication list ECAT Foundation
Special Issue

Guidelines

Diagnosis and classification of factor XIII deficiencies, SSC recommendation
Guidance for INR and D-dimer testing using point of care testing in primary care, ICSH recommendations
Guidance for New Lot Verification of Coagulation Reagents, Calibrators, and Controls, ICSH recommendations
ICSH Recommendations for Hemostasis Critical Values, Tests, and Reporting
ICSH Recommendations for laboratory measurement of ADAMTS13
ICSH Recommendations for Laboratory Measurement of Direct Oral Anticoagulants
Laboratory guidance for the evaluation of haemostasis analyser-reagent test systems. Part 1: Instrument-specific issues and commonly used coagulation screening tests. ICSH Recommendations
Laboratory guidance for the verification of haemostasis analyser-reagent test systems. Part 2: Specialist tests and calibrated assays, ICSH recommendations
Recommendations for collection of blood samples for coagulation testing, ICSH recommendations
Recommendations for laboratory measurement of factor VIII and FIX type I inhibitors, ICSH recommendations
Recommendations for processing of blood samples for coagulation testing, ICSH recommendations
Recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders, ICSH recommendations
Thrombin generation measurement in haemophilia, SSC recommendation
Update Recommendations for Laboratory Measurement of Direct Oral Anticoagulants, ICSH recommendations

Haemostatic Cascade

Activation of Platelets by Thrombin
Activation of Protein C by Thrombin
Activation of TAFI by Thrombin
Amino Acid structure of Natural Hirudin
Coagulation Pathways (All Components)
Fibrinolytic Pathway
Intrinsic Pathway APTT
Nucleotide sequences of RNA Codons Encoding for Amino Acids
TF Pathway (Extrinsic) with Common Pathway (PT)

Parameter

Diversity in testing for platelet function disorders by light transmission aggregometry in the Netherlands
Laboratory Tests
Test Information

Quality Issues

Algorithm A, a new statistical approach for the evaluation of survey results
Assuring quality in the postanalytical phase
Bayesian strategy in long-term IQC results management: practical interest and compliance with standards
Defining analytical performance specifications: Consensus Statement from the 1st Strategic Conference of the European Federation of Clinical Chemistry and Laboratory Medicine
Does quality matter?
External quality assessment for Rivaroxaban and Dabigatran
External quality assessment / proficiency testing for platelet function disorders
External quality assessment for Factor VIII and Factor IX
External quality assessment for Factor XIII
External quality assessment for immunological Heparin-Induced Thrombocytopenia testing
External quality assessment for von Willebrand Factor laboratory analysis
External Quality Assessment in haemostasis
Internal Quality Control for Coagulation: Repeating the same mistakes as chemistry? Or leaping ahead into the 21st century?
Interpretation of the Z-score
Long-term evaluation of EQA results
Quality Assurance of replacement therapy and future perspectives
Quality control in the haemostasis laboratory
Results of the surveys for heparin monitoring
Risk management for laboratory testing
The between-laboratoy variation of Factor VIII inhibitor testing
The relevance of accreditation for medical laboratories: An added value for patient care
The use of quality indicators for the pre-analytical phase
Validation of methods in hemostasis testing: a practical approach
Wet Workshop on Platelet Function Testing

Surveys and Studies

A severe haemophilia A patient treated with emicizumab, case study
Acquired Hemophilia A, case study
Dysfibrinogenemia, case study
External quality assessment for Rivaroxaban and Dabigatran
External quality assessment for Factor VIII and Factor IX
External quality assessment for Factor XIII
External quality assessment for immunological Heparin-Induced Thrombocytopenia testing
External quality assessment for von Willebrand Factor laboratory analysis
Haemophilia A and treatment, case study
Haemophilia B and treatment, case study
The between-laboratoy variation of Factor VIII inhibitor testing
The effect of Rivaroxaban on haemostasis assays; results from ECAT surveys
Trauma-Induced Coagulopathy, case study
Von Willebrand Disease type 1, case study
Von Willebrand Disease type 2B, case study
Von Willebrand Jürgens syndrome type I, case study 2016
Von Willebrand Jürgens syndrome type I, case study 2019

Terminology

Terminology

Laboratory Tests

Activated Clotting Time (ACT)
Activated Partial Thromboplastin Time (APTT)
Activated Protein C resistance (APC-R)
ADAMTS13 activity, antigen and inhibitor
Anti-Xa (Clotting-based and Chromogenic)
Anticardiolipin (aCL) and Anti-β2-Glycoprotein I (Anti-β2GPI)
Antithrombin (Chromogenic and Immunological)
Ecarin Clotting Time
Factor Assays APTT-Based (1-Stage)
Factor Assays PT-Based (1-Stage)
Factor IX (Chromogenic)
Factor V Leiden (F5 Arg506Gln)
Factor VIII (Clotting-based and Chromogenic)
Factor VIII Binding (VWF:FVIIIB)
Factor VIII inhibitor
Factor X Assay (RVV)
Factor XIII
Fibrinogen
Fibrinolysis: D-Dimer
Fibrinolysis: Euglobulin Clot Lysis Time (ECLT)
Fibrinolysis: Fibrinogen Degradation Products (FDP)
Fibrinolysis: Global Fibrinolytic Capacity (GFC) and Clot Formation and Lysis (CloFAL)
Fibrinolysis: Plasminogen (Plg)
Fibrinolysis: Plasminogen Activator Inhibitor Type 1 (PAI-1): Serpin E1
Fibrinolysis: Thrombin Activatable Fibrinolysis Inhibitor (TAFI)
Fibrinolysis: Tissue-type Plasminogen Activator (t-PA)
Fibrinolysis: Urokinase-type Plasminogen Activator (u-PA)
Fibrinolysis: Venous Occlusion Test
Fibrinolysis: α2-Plasmin Inhibitor
Global Thrombosis Test (GTT)
Heparin Cofactor II (HCII)
Heparin Induced Thrombocytopenia (HIT), Anti-Platelet Factor 4 (PF4)
Homocysteine (Hcy)
International Sensitivity Index (ISI) & The International Normalised Ratio (INR)
Lupus Anticoagulant (LA): Dilute Russell Viper Venom Time (dRVVT)
Lupus Anticoagulant (LA): Dilute Thromboplastin Inhibition (DTI)
Lupus Anticoagulant (LA): Kaolin Clotting Time (KCT)
Lupus Anticoagulant (LA): Silica Clotting Time (SCT)
Lupus Anticoagulant (LA): Taipan Venom Time
Lupus Anticoagulant (LA): Textarin:Ecarin Ratio and Taipan:Ecarin Ratio
Platelet Function: Flow Cytometry
Platelet Function: Impedance Platelet Aggregometry
Platelet Function: Light Transmission Aggregometry (LTA)
Platelet Function: PFA-100/200
Platelet Function: Platelet Nucleotides
Platelet Function: Platelet Procoagulant Activity (PCA)
Platelet Function: VerifyNow
Protamine Sulphate Neutralisation Test
Protein C (Clotting-based, Immunological and Chromogenic)
Protein C (ProC) Global Assay
Protein S (Clotting-based and Immunological)
Prothrombin (F2) G20210A Mutation
Prothrombin Fragment 1+2 (F1+2)
Prothrombin Time (PT)
Prothrombinase-induced Clotting Test (PiCT)
ReoRox G2
Reptilase (Batroxobin) Time
Ristocetin-Induced Platelet Agglutination (RIPA)
The Bleeding Time (BT)
Thrombin Generation (Clotting-based, Chromogenic and Fluorogenic)
Thrombin Time (TT)
Thromboelastography (TEG) & Rotational Thromboelastometry (ROTEM)
Von Willebrand Collagen Binding (VWF:CB)
Von Willebrand Factor (VWF) Inhibitor
Von Willebrand Factor (VWF) Multimers
Von Willebrand Factor Activity (VWF:Act)
Von Willebrand Factor antigeen (VWF:Ag)
Von Willebrand Factor Propeptide (VWFpp)
Von Willebrand Factor Ristocetin Cofactor (VWF:RCo)

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