Haemophilia, Clinical and Laboratory Aspects
Haemophilia is a rare disorder and patients who suffer from severe haemophilia have several bleedings per year. To prevent bleeding in these patients treatment is necessary. This is why this special issue provides information about the development of treatments and the insights regarding assays to monitor these treatments and to make an accurate diagnosis.
The first section focuses on the clinical aspects and gives a short overview of haemophilia, the clinical aspects and treatment, contains an article focusing on the considerations for a patient-tailored therapy for haemophilia A, describes the possibility of optimizing prophylactic treatment, discusses the risk factors and treatment of inhibitor development in mild/moderate haemophilia A and provides a narrative review of new treatment strategies that are under development for haemophilia.
The second part, with a focus on the laboratory aspects of measuring FVIII coagulant activity with a contribution on the measurement of factor VIII with different assays and their pitfalls, an article about the genetic background of haemophilia and a contribution about the laboratory monitoring of new haemostatic agents. The last contribution gives an overview of external quality assessment results for haemophilia diagnostics.